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Molecular Targets in Protein Misfolding and Neurodegenerative Disease (ORIGINAL PDF from Publisher)

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by Pierfausto Seneci

Aimed at “drug discoverers” – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc.

  • Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases
  • Provides a “drug discovery” application oriented perspective, evaluating targets and candidates for their overall therapeutic potential
  • Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development
  • Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area
  • Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets

Product Details

  • ISBN-13: 9780128001868
  • Publisher: Elsevier Science
  • Publication date: 12/15/2014
  • Pages: 320

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